T-bet and interleukin-27: possible TH1 immunomodulators of sarcoidosis
نویسندگان
چکیده
منابع مشابه
T-bet and mucosal Th1 responses in the gastrointestinal tract.
T cells play an essential role in regulating mucosal immune responses in the gastrointestinal tract. Recent observations on T helper cell differentiation and activation by regulatory transcription factors-especially T-bet-in chronic inflammatory diseases have provided new perspectives for understanding mucosal immunity. Here we summarise recent advances in the field of transcription factors and...
متن کاملA Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
Naive T helper cells differentiate into two subsets, Th1 and Th2, each with distinct functions and cytokine profiles. Here, we report the isolation of T-bet, a Th1-specific T box transcription factor that controls the expression of the hallmark Th1 cytokine, IFNgamma. T-bet expression correlates with IFNgamma expression in Th1 and NK cells. Ectopic expression of T-bet both transactivates the IF...
متن کاملInterleukin-27 in T Cell Immunity
Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic properties that can enhance or limit immune responses. IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells. Intensive studies have been conducted especially on T cells, revealing that various subsets of T ce...
متن کاملT-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.
Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. By adding Stat6 deficiency to T-bet deficiency, and thus negating effects from elevated levels of IL-4/Stat6/GATA3 Th2 signals in T-bet-deficient cells, we investigated the signals important for Th1 and Th17 cell differentiation and their role in colitis development. The data reveal that Eomesodermin compens...
متن کاملA crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells.
Proinflammatory T helper 1 (Th1) cells express high levels of carbohydrate ligands for the endothelial selectins, but the molecular basis for this phenotype is incompletely understood. We document here a significant role in selectin ligand formation for the recently described Th1 transcription factor T-bet. Th1 cells generated from T-bet-/- mice showed significantly lower levels of ligands for ...
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ژورنال
عنوان ژورنال: Inflammopharmacology
سال: 2015
ISSN: 0925-4692,1568-5608
DOI: 10.1007/s10787-015-0247-y